However, please let us know if you are planning to conceive or as soon as you know you are pregnant. You've successfully added to your alerts. Generic Name : Carbimazole Pronunciation : car-bim-a-zole Latest prescription information about Carbimazole. New information is continually becoming available. fewer than after PTU use). Learning and behavioural problems A baby’s brain continues to develop right up until the end of pregnancy. Impact of Carbimazole, Thiamazole (Methimazole) during pregnancy on fetal development, risk of stillbirth, malformation or birth defects. Methimazole Uses: ... Pregnancy Risk Factor D. Methimazole can cross the placenta. However, none of four small scientific studies have shown that children exposed to carbimazole or methimazole in the womb are more likely to have problems with learning and behaviour than children not exposed to these medicines. Carbimazole is associated with an increased risk of congenital malformations, especially when administered in the first trimester of pregnancy and at high doses. This factsheet has been written for members of the public by the UK Teratology Information Service (UKTIS). Endocrine Today | Untreated hyperthyroidism in pregnancy places the mother and child at an elevated risk for a number of adverse outcomes, including preeclampsia and congestive heart failure. Women who have been treated with carbimazole or methimazole during the first trimester may be offered the option of having earlier and more detailed anomaly scans to look for birth defects in addition to the main scan for birth defects which is generally offered at around 20 weeks. Reference: MRHA (February 2019). More research is required before we can say whether taking carbimazole in pregnancy is specifically linked to low birth weight in the baby. We would not expect any increased risk to your baby if the father took carbimazole or methimazole before or around the time you became pregnant. Close maternal, foetal and neonatal monitoring is warranted (see Section 4.6 Fertility, pregnancy and lactation, Use in pregnancy). For case-specific advice please contact UKTIS on 0344 892 0909. UKTIS is a not-for-profit organisation funded by Public Health England on behalf of UK Health Departments. Carbimazole is an antithyroid medicine, which is used for treating hyperthyroidism. Carbimazole crosses the placenta but, provided the mother's dose is within the standard range and her thyroid status is monitored; there is no evidence of neonatal thyroid abnormalities. Carbimazole may still be used during pregnancy at low doses and under close medical supervision. These include choanal atresia (where the opening at the back of one or both nostrils is blocked by extra bone or tissue), problems with the development of the heart or digestive system and abdominal wall, and a scalp defect called aplasia cutis (where there are gaps in the skin on the scalp). Therefore, carbimazole should be used in pregnancy only when propylthiouracil is not suitable. Carbimazole is associated with an increased risk of congenital malformations when used during pregnancy, especially in the first trimester and at high doses (daily dose of 15 mg or more). Consult a doctor before its use if: You are pregnant, planning for it or are breastfeeding ; … Use of carbimazole in pregnancy, especially during the first trimester, and at doses greater than 15mg per day, is associated with an increased risk of congenital malformations. Read about its interactions, intake instructions and how Carbimazole works only on PharmEasy. The concept of a carbimazole embryopathy underlies current Endocrine Society advice to avoid this drug in early pregnancy, favouring propylthiouracil as an alternative for the treatment of maternal hyperthyroidism. The main points about which to raise awareness are: 1. Eleven mothers were taking oral carbimazole in dosages ranging from 5 to 20 mg daily during pregnancy and 5 to 15 mg daily during breastfeeding (extent not stated). There is no firm evidence to link CMZ/MMI exposure during pregnancy to miscarriage, perinatal death and premature delivery, although for most of these outcomes data are inadequate to permit a full and accurate risk assessment. thyroid hormone substitutes will be needed. Links: carbimazole; The information provided herein should not be used for diagnosis or treatment of any medical condition. QJM 2012; 105:189. If carbimazole is used during pregnancy, close maternal, foetal and neonatal monitoring is recommended (see section 4.4). It is therefore possible that taking certain medicines at any stage of pregnancy could have a lasting effect on a child’s learning or behaviour. The prevalence of hyperthyroidism (overactive thyroid) during pregnancy ranges from 0.05 to 0.2%. A large number of case reports (>70) and numerous case-control and cohort studies have linked exposure to carbimazole/methimazole (CMZ/MMI) during early pregnancy with an embryopathy that incorporates a number of birth defects including aplasia cutis, choanal atresia, gastrointestinal anomalies and abdominal wall defects. 2 Treatment of active epilepsy is important during pregnancy because seizures can lead to falls, injury, and physical stress that can endanger the health of the woman and … Although the relative risk of these specific and often rare malformations appears to be greatly increased following exposure to CMZ/MMI, one large study has estimated that <2% of infants exposed to CMZ/MMI in utero will have at least one of these malformations, suggesting that teratogenic effects are relatively uncommon and the absolute risk of embryopathy is low. 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